First you should think about what application would be the best to
handle/store your data.
Is for instance Access an option ?
Be aware of the fact Excel isen't a real DB application but more a "calculation" program.
What kind and how much data you need to handle...?
If you want to link Excel to your VB application then i would advice you
to take a look at these threads which handles the basics of linking VB with Excel.
Take a look at these threads...
Additional you could use this forum's excellent search tool and search
for words like "open,close,save,quit,application" etc....
Hope this gets you started.