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Assuming you have the permissions, you could establish some sort of inter-process link (over network, etc.) between your "main" program and the "slave" programs on the remote PCs. This link could then deliver commands to the slave programs which would direct them to do the appropriate writing to the registry.
You would, of course, have to have written such functionality into the slave programs, but it sounds like this is a situation where you can do that.
For some more information on inter-process communications check out our Tutor's Corner - there are several examples based on different technologies.
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